The Sustained effects on tear volume of pilocarpine hydrochloride in gelatin by hydrogel administered by an implant-mediated drug delivery system
Identifieur interne : 000043 ( Main/Exploration ); précédent : 000042; suivant : 000044The Sustained effects on tear volume of pilocarpine hydrochloride in gelatin by hydrogel administered by an implant-mediated drug delivery system
Auteurs : Seunghee Cha [États-Unis] ; Hong-Kyun Kim [Corée du Sud] ; Hong-Seop Kho ; Young-Seok Park [Corée du Sud]Source :
- Current drug delivery [ 1567-2018 ] ; 2017.
Abstract
Pilocarpine hydrochloride is commonly prescribed to patients with dry mouth and eye using a frequent dosing schedule. The aim of this study was to evaluate the sustained effects of this highly soluble drug carried by a gelatin hydrogel, which was administered by an implant mediated drug delivery system (IMDDS). The IMDDS was installed in a total of 24 rabbits. After complete healing, pilocarpine hydrochloride was administered as 30 mg as raw powder (Group 1; n = 8), 30 mg in gelatin hydrogel (Group 2; n = 8), and 60 mg in gelatin hydrogel (Group 3; n = 8). The effects were evaluated by tear volume measured using the Schirmer tear test for 2 weeks after administration. All 3 groups showed an increase in tear volume from the initial measurement at 1 hour. Group 1 exhibited this increase for 24 hours, while Groups 2 and 3 sustained this increase for 5 days and 7.5 days, respectively. When provided in gelatin hydrogel, highly water-soluble pilocarpine hydrochloride administered through IMDDS resulted in sustained effects with increased tear volume in normal rabbits.
Url:
DOI: 10.2174/1567201813666161013150648
PubMed: 27739377
PubMed Central: 5561526
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002637
- to stream Pmc, to step Curation: 002637
- to stream Pmc, to step Checkpoint: 000036
- to stream Ncbi, to step Merge: 006B03
- to stream Ncbi, to step Curation: 006B03
- to stream Ncbi, to step Checkpoint: 006B03
- to stream Main, to step Merge: 000043
- to stream Main, to step Curation: 000043
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Sustained effects on tear volume of pilocarpine hydrochloride in gelatin by hydrogel administered by an implant-mediated drug delivery system</title><author><name sortKey="Cha, Seunghee" sort="Cha, Seunghee" uniqKey="Cha S" first="Seunghee" last="Cha">Seunghee Cha</name><affiliation wicri:level="1"><nlm:aff id="A1">Oral and Mxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, U.S.A</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Oral and Mxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville</wicri:regionArea><wicri:noRegion>Gainesville</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hong Kyun" sort="Kim, Hong Kyun" uniqKey="Kim H" first="Hong-Kyun" last="Kim">Hong-Kyun Kim</name><affiliation wicri:level="4"><nlm:aff id="A2">Departmentof Oral Anatomy,School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Departmentof Oral Anatomy,School of Dentistry and Dental Research Institute, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Kho, Hong Seop" sort="Kho, Hong Seop" uniqKey="Kho H" first="Hong-Seop" last="Kho">Hong-Seop Kho</name><affiliation><nlm:aff id="A3">Department of Oral Medicine and Oral Diagnosis, Seoul National Univerist, Seoul, Repubpic of Korea</nlm:aff><wicri:noCountry code="subfield">Repubpic of Korea</wicri:noCountry></affiliation></author><author><name sortKey="Park, Young Seok" sort="Park, Young Seok" uniqKey="Park Y" first="Young-Seok" last="Park">Young-Seok Park</name><affiliation wicri:level="3"><nlm:aff id="A4">Department of Oral Anatomy, Seoul National Univeristy School of Dentistry, P.O. Box: 03080, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Oral Anatomy, Seoul National Univeristy School of Dentistry, P.O. Box: 03080, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27739377</idno><idno type="pmc">5561526</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561526</idno><idno type="RBID">PMC:5561526</idno><idno type="doi">10.2174/1567201813666161013150648</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002637</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002637</idno><idno type="wicri:Area/Pmc/Curation">002637</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002637</idno><idno type="wicri:Area/Pmc/Checkpoint">000036</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000036</idno><idno type="wicri:Area/Ncbi/Merge">006B03</idno><idno type="wicri:Area/Ncbi/Curation">006B03</idno><idno type="wicri:Area/Ncbi/Checkpoint">006B03</idno><idno type="wicri:doubleKey">1567-2018:2017:Cha S:the:sustained:effects</idno><idno type="wicri:Area/Main/Merge">000043</idno><idno type="wicri:Area/Main/Curation">000043</idno><idno type="wicri:Area/Main/Exploration">000043</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Sustained effects on tear volume of pilocarpine hydrochloride in gelatin by hydrogel administered by an implant-mediated drug delivery system</title><author><name sortKey="Cha, Seunghee" sort="Cha, Seunghee" uniqKey="Cha S" first="Seunghee" last="Cha">Seunghee Cha</name><affiliation wicri:level="1"><nlm:aff id="A1">Oral and Mxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, U.S.A</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Oral and Mxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville</wicri:regionArea><wicri:noRegion>Gainesville</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hong Kyun" sort="Kim, Hong Kyun" uniqKey="Kim H" first="Hong-Kyun" last="Kim">Hong-Kyun Kim</name><affiliation wicri:level="4"><nlm:aff id="A2">Departmentof Oral Anatomy,School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Departmentof Oral Anatomy,School of Dentistry and Dental Research Institute, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Kho, Hong Seop" sort="Kho, Hong Seop" uniqKey="Kho H" first="Hong-Seop" last="Kho">Hong-Seop Kho</name><affiliation><nlm:aff id="A3">Department of Oral Medicine and Oral Diagnosis, Seoul National Univerist, Seoul, Repubpic of Korea</nlm:aff><wicri:noCountry code="subfield">Repubpic of Korea</wicri:noCountry></affiliation></author><author><name sortKey="Park, Young Seok" sort="Park, Young Seok" uniqKey="Park Y" first="Young-Seok" last="Park">Young-Seok Park</name><affiliation wicri:level="3"><nlm:aff id="A4">Department of Oral Anatomy, Seoul National Univeristy School of Dentistry, P.O. Box: 03080, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Oral Anatomy, Seoul National Univeristy School of Dentistry, P.O. Box: 03080, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Current drug delivery</title><idno type="ISSN">1567-2018</idno><idno type="eISSN">1875-5704</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Pilocarpine hydrochloride is commonly prescribed to patients with dry mouth and eye using a frequent dosing schedule. The aim of this study was to evaluate the sustained effects of this highly soluble drug carried by a gelatin hydrogel, which was administered by an implant mediated drug delivery system (IMDDS). The IMDDS was installed in a total of 24 rabbits. After complete healing, pilocarpine hydrochloride was administered as 30 mg as raw powder (Group 1; n = 8), 30 mg in gelatin hydrogel (Group 2; n = 8), and 60 mg in gelatin hydrogel (Group 3; n = 8). The effects were evaluated by tear volume measured using the Schirmer tear test for 2 weeks after administration. All 3 groups showed an increase in tear volume from the initial measurement at 1 hour. Group 1 exhibited this increase for 24 hours, while Groups 2 and 3 sustained this increase for 5 days and 7.5 days, respectively. When provided in gelatin hydrogel, highly water-soluble pilocarpine hydrochloride administered through IMDDS resulted in sustained effects with increased tear volume in normal rabbits.</p></div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement><orgName><li>Université nationale de Séoul</li></orgName></list><tree><noCountry><name sortKey="Kho, Hong Seop" sort="Kho, Hong Seop" uniqKey="Kho H" first="Hong-Seop" last="Kho">Hong-Seop Kho</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Cha, Seunghee" sort="Cha, Seunghee" uniqKey="Cha S" first="Seunghee" last="Cha">Seunghee Cha</name></noRegion></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Hong Kyun" sort="Kim, Hong Kyun" uniqKey="Kim H" first="Hong-Kyun" last="Kim">Hong-Kyun Kim</name></region><name sortKey="Park, Young Seok" sort="Park, Young Seok" uniqKey="Park Y" first="Young-Seok" last="Park">Young-Seok Park</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000043 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000043 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5561526
|texte= The Sustained effects on tear volume of pilocarpine hydrochloride in gelatin by hydrogel administered by an implant-mediated drug delivery system
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27739377" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |